TANGNEY LAB
PUBLICATIONS
1.         Hogan G, Walker SP, Turnbull F, Curiao T, Morrison AA, Flores Bueso Y, et al. Microbiome analysis as a platform R&D tool for parasitic nematode disease management. ISME J. In Press.
2.         Suff N, Karda R, Diaz JA, Ng J, Baruteau J, Perocheau D, et al. Ascending Vaginal Infection Using Bioluminescent Bacteria Evokes Intrauterine Inflammation, Preterm Birth, and Neonatal Brain Injury in Pregnant Mice. The American journal of pathology. 2018 Oct;188(10):2164-76. PubMed PMID: 30036519. Pubmed Central PMCID: 6168615.
3.         O'Connor H, MacSharry J, Bueso YF, Lindsay S, Kavanagh EL, Tangney M, et al. Resident bacteria in breast cancer tissue: pathogenic agents or harmless commensals? Discov Med. 2018 Sep;26(142):93-102. PubMed PMID: 30399327.
4.         Hogan G, Tangney M. The Who, What, and Why of Drug Discovery and Development. Trends Pharmacol Sci. 2018 Oct;39(10):848-52. PubMed PMID: 30196936.
5.         Flores Bueso Y, Lehouritis P, Tangney M. In situ biomolecule production by bacteria; a synthetic biology approach to medicine. J Control Release. 2018 Feb 22;275:217-28. PubMed PMID: 29477351.
6.         Ur Rahman S, Stanton M, Casey PG, Spagnuolo A, Bensi G, Hill C, et al. Development of a Click Beetle Luciferase Reporter System for Enhanced Bioluminescence Imaging of Listeria monocytogenes: Analysis in Cell Culture and Murine Infection Models. Front Microbiol. 2017;8:1797. PubMed PMID: 29018414. Pubmed Central PMCID: 5622934.
7.         Murphy C, Rettedal E, Lehouritis P, Devoy C, Tangney M. Intratumoural production of TNFalpha by bacteria mediates cancer therapy. PLoS One. 2017;12(6):e0180034. PubMed PMID: 28662099. Pubmed Central PMCID: 5491124.
8.         Lehouritis P, Hogan G, Tangney M. Designer bacteria as intratumoural enzyme biofactories. Adv Drug Deliv Rev. 2017 Sep 1;118:8-23. PubMed PMID: 28916496.
9.         Flores Bueso Y, Tangney M. Synthetic Biology in the Driving Seat of the Bioeconomy. Trends Biotechnol. 2017 May;35(5):373-8. PubMed PMID: 28249675.
10.       Urbaniak C, Gloor GB, Brackstone M, Scott L, Tangney M, Reid G. The Microbiota of Breast Tissue and Its Association with Breast Cancer. Appl Environ Microbiol. 2016 Aug 15;82(16):5039-48. PubMed PMID: 27342554. Pubmed Central PMCID: 4968547.
11.       Lehouritis P, Stanton M, McCarthy FO, Jeavons M, Tangney M. Activation of multiple chemotherapeutic prodrugs by the natural enzymolome of tumour-localised probiotic bacteria. J Control Release. 2016 Jan 28;222:9-17. PubMed PMID: 26655063.
12.       Cronin M, Akin AR, Francis KP, Tangney M. In Vivo Bioluminescence Imaging of Intratumoral Bacteria. Methods Mol Biol. 2016;1409:69-77. PubMed PMID: 26846803.
13.       Vorobyeva AG, Stanton M, Godinat A, Lund KB, Karateev GG, Francis KP, et al. Development of a Bioluminescent Nitroreductase Probe for Preclinical Imaging. PLoS One. 2015;10(6):e0131037. PubMed PMID: 26110789.
14.       Stanton M, Cronin M, Lehouritis P, Tangney M. In vivo bacterial imaging without engineering; A novel probe-based strategy facilitated by endogenous nitroreductase enzymes. Curr Gene Ther. 2015;15(3):277-88. PubMed PMID: 25619884.
15.       Lehouritis P, Cummins J, Stanton M, Murphy CT, McCarthy FO, Reid G, et al. Local bacteria affect the efficacy of chemotherapeutic drugs. Sci Rep. 2015 Sep 29;5:14554. PubMed PMID: 26416623. Pubmed Central PMCID: 4586607.
16.       Byrne WL, Tangney M. Bacteria as Gene Therapy Vectors for Cancer. In: Smyth Templeton N, editor. Gene and Cell Therapy: Therapeutic Mechanisms and Strategies. Fourth ed: CRC Press; 2015.
17.       Whelan MC, Casey G, Larkin JO, Guinn BA, O'Sullivan GC, Tangney M. Oral tolerance to cancer can be abrogated by T regulatory cell inhibition. PLoS One. 2014;9(5):e97602. PubMed PMID: 24832130.
18.       Urbaniak C, Cummins J, Brackstone M, Macklaim JM, Gloor GB, Baban CK, et al. Microbiota of human breast tissue. Appl Environ Microbiol. 2014 May;80(10):3007-14. PubMed PMID: 24610844.
19.       Cummins J, Cronin M, van Pijkeren JP, Gahan CG, Tangney M. Bacterial systems for gene delivery to systemic tumors. Methods Mol Biol. 2014;1141:201-9. PubMed PMID: 24567141.
20.       Cronin M, Le Boeuf F, Murphy C, Roy DG, Falls T, Bell JC, et al. Bacterial-mediated knockdown of tumor resistance to an oncolytic virus enhances therapy. Mol Ther. 2014 Jun;22(6):1188-97. PubMed PMID: 24569832. Pubmed Central PMCID: 4048890.
21.       Byrne WL, Murphy CT, Cronin M, Wirth T, Tangney M. Bacterial-mediated DNA delivery to tumour associated phagocytic cells. J Control Release. 2014 Dec 28;196:384-93. PubMed PMID: 25466954.
22.       Rajendran S, O'Sullivan GC, O'Hanlon D, Tangney M. Adenovirus-mediated transcriptional targeting of colorectal cancer and effects on treatment-resistant hypoxic cells. Clin Colorectal Cancer. 2013 Sep;12(3):152-62 e1. PubMed PMID: 23313233.
23.       Morrissey D, Collins SA, Rajendran S, Casey G, O'Sullivan GC, Tangney M. Plasmid Transgene Expression In Vivo; Promoter and Tissue Variables. In: Molina FM, editor. Gene Therapy - Tools and Potential Applications: InTech; 2013.
24.       Lehouritis P, Springer C, Tangney M. Bacterial-directed enzyme prodrug therapy. J Control Release. 2013 Aug 28;170(1):120-31. PubMed PMID: 23688772.
25.       Cummins J, Tangney M. Bacteria and tumours: causative agents or opportunistic inhabitants? Infect Agent Cancer. 2013;8(1):11. PubMed PMID: 23537317. Pubmed Central PMCID: 3668256.
26.       Byrne WL, DeLille A, Kuo C, de Jong JS, van Dam GM, Francis KP, et al. Use of optical imaging to progress novel therapeutics to the clinic. J Control Release. 2013 Dec 10;172(2):523-34. PubMed PMID: 23680286.
27.       Boncheva V, Bonney SA, Brooks SE, Tangney M, O'Sullivan G, Mirnezami A, et al. New targets for the immunotherapy of colon cancer-does reactive disease hold the answer? Cancer Gene Ther. 2013 Mar;20(3):157-68. PubMed PMID: 23492821.
28.       Tangney M, Francis KP. In vivo optical imaging in gene & cell therapy. Curr Gene Ther. 2012 Feb 1;12(1):2-11. PubMed PMID: 22263919. Epub 2012/01/24. eng.
29.       Tangney M. Editorial: in vivo imaging & gene therapy. Curr Gene Ther. 2012 Feb 1;12(1):1. PubMed PMID: 22348524. Epub 2012/02/22. eng.
30.       Morrissey D, van Pijkeren JP, Rajendran S, Collins SA, Casey G, O'Sullivan GC, et al. Control and augmentation of long-term plasmid transgene expression in vivo in murine muscle tissue and ex vivo in patient mesenchymal tissue. J Biomed Biotechnol. 2012;2012:379845. PubMed PMID: 22811595. Pubmed Central PMCID: 3395381. Epub 2012/07/20. eng.
31.       Laga R, Carlisle R, Tangney M, Ulbrich K, Seymour LW. Polymer coatings for delivery of nucleic acid therapeutics. J Control Release. 2012 Feb 18. PubMed PMID: 22366547. Epub 2012/03/01. Eng.
32.       Cronin M, Stanton RM, Francis KP, Tangney M. Bacterial vectors for imaging and cancer gene therapy: a review. Cancer Gene Ther. 2012 Nov;19(11):731-40. PubMed PMID: 22996740.
33.       Cronin M, Akin AR, Collins SA, Meganck J, Kim JB, Baban CK, et al. High resolution in vivo bioluminescent imaging for the study of bacterial tumour targeting. PLoS One. 2012;7(1):e30940. PubMed PMID: 22295120. Pubmed Central PMCID: 3266281.
34.       Collins SA, Hiraoka K, Inagaki A, Kasahara N, Tangney M. PET Imaging for Gene & Cell Therapy. Curr Gene Ther. 2012 Feb 1;12(1):20-32. PubMed PMID: 22263921. Epub 2012/01/24. eng.
35.       Collins JW, Akin AR, Kosta A, Zhang N, Tangney M, Francis KP, et al. Pre-treatment with Bifidobacterium breve UCC2003 modulates Citrobacter rodentium-induced colonic inflammation and organ specificity of infection. Microbiology. 2012 Aug 17. PubMed PMID: 22902730. Epub 2012/08/21. Eng.
36.       Bhattacharya S, Wilson C. The fightback. New Scientist. 2012 10/13/:38-41.
37.       Baban CK, Cronin M, Akin AR, O'Brien A, Gao X, Tabirca S, et al. Bioluminescent bacterial imaging in vivo. J Vis Exp. 2012 (69). PubMed PMID: 23149597.
38.       Ahmad S, Sweeney P, Sullivan GC, Tangney M. DNA vaccination for prostate cancer, from preclinical to clinical trials - where we stand? Genet Vaccines Ther. 2012;10(1):9. PubMed PMID: 23046944.
39.       Rajendran S, O'Hanlon D, Morrissey D, O'Donovan T, O'Sullivan GC, Tangney M. Preclinical evaluation of gene delivery methods for the treatment of loco-regional disease in breast cancer. Exp Biol Med (Maywood). 2011 Apr 1;236(4):423-34. PubMed PMID: 21444371. Epub 2011/03/30. eng.
40.       Rajendran S, Collins S, van Pijkeren JP, O'Hanlon D, O'Sullivan GC, Tangney M. Targeting of Breast Metastases Using a Viral Gene Vector with Tumour-selective Transcription. Anticancer Res. 2011 May;31(5):1627-35. PubMed PMID: 21617219. Epub 2011/05/28. eng.
41.       Collins SA, Morrissey D, Rajendran S, Casey G, Scallan MF, Harrison PT, et al. Comparison of DNA Delivery and Expression Using Frequently Used Delivery Methods. In: Kang C, editor. Gene Therapy - developments and future perspectives: InTech; 2011.
42.       Bourke MG, Salwa S, Harrington KJ, Kucharczyk MJ, Forde PF, de Kruijf M, et al. The emerging role of viruses in the treatment of solid tumours. Cancer Treat Rev. 2011 Dec;37(8):618-32. PubMed PMID: 21232872.
43.       Ahmad S, Casey G, Cronin M, Rajendran S, Sweeney P, Tangney M, et al. Induction of effective antitumor response after mucosal bacterial vector mediated DNA vaccination with endogenous prostate cancer specific antigen. J Urol. 2011 Aug;186(2):687-93. PubMed PMID: 21683415. Epub 2011/06/21. eng.
44.       Whelan MC, Casey G, MacConmara M, Lederer JA, Soden D, Collins JK, et al. Effective immunotherapy of weakly immunogenic solid tumours using a combined immunogene therapy and regulatory T-cell inactivation. Cancer Gene Ther. 2010 Jul;17(7):501-11. PubMed PMID: 20186173. Epub 2010/02/27. eng.
45.       van Pijkeren JP, Morrissey D, Monk IR, Cronin M, Rajendran S, O'Sullivan GC, et al. A novel Listeria monocytogenes-based DNA delivery system for cancer gene therapy. Hum Gene Ther. 2010 Apr;21(4):405-16. PubMed PMID: 20105075. Epub 2010/01/29. eng.
46.       Tangney M, van Pijkeren JP, Gahan CG. The use of Listeria monocytogenes as a DNA delivery vector for cancer gene therapy. Bioeng Bugs. 2010 Jul;1(4):284-7. PubMed PMID: 21327062. Pubmed Central PMCID: 3026469. Epub 2011/02/18. eng.
47.       Tangney M, Gahan CG. Listeria monocytogenes as a vector for anti-cancer therapies. Curr Gene Ther. 2010 Feb;10(1):46-55. PubMed PMID: 20158470.
48.       Tangney M, Gahan CG. Editorial [Hot Topic: Bacterial Vectors for Gene & Cell Therapy]. Curr Gene Ther. 2010 Feb;10(1):1-2. PubMed PMID: 20230364. Epub 2010/03/17. eng.
49.       Tangney M, Ahmad S, Collins SA, O'Sullivan GC. Gene therapy for prostate cancer. Postgrad Med. 2010 May;122(3):166-80. PubMed PMID: 20463426. Epub 2010/05/14. eng.
50.       Tangney M. Gene therapy for cancer: dairy bacteria as delivery vectors. Discov Med. 2010 Sep;10(52):195-200. PubMed PMID: 20875340. Epub 2010/09/30. eng.
51.       Rajendran S, Salwa S, Gao X, Tabirca S, O'Hanlon D, O'Sullivan GC, et al. Ex vivo culture of patient tissue & examination of gene delivery. J Vis Exp. 2010 (46). PubMed PMID: 21326169. Epub 2011/02/18. eng.
52.       Rajendran S, Salwa S, Gao X, Tabirca S, O'Hanlon D, O'Sullivan GC, et al. Murine bioluminescent hepatic tumour model. J Vis Exp. 2010 (41). PubMed PMID: 20689502. Epub 2010/08/07. eng.
53.       Morrissey D, O'Sullivan GC, Tangney M. Tumour targeting with systemically administered bacteria. Curr Gene Ther. 2010 Feb;10(1):3-14. PubMed PMID: 20156191.
54.       Guinn B, Casey G, Moller MG, Kasahara N, O'Sullivan GC, Peng KW, et al. International Society for Cell and Gene Therapy of Cancer 2009 Annual Meeting held in Cork, Ireland. Hum Gene Ther. 2010 Jan;21(1):9-26. PubMed PMID: 20017714. Epub 2009/12/19. eng.
55.       Cronin M, Morrissey D, Rajendran S, El Mashad SM, van Sinderen D, O'Sullivan GC, et al. Orally administered bifidobacteria as vehicles for delivery of agents to systemic tumors. Mol Ther. 2010 Jul;18(7):1397-407. PubMed PMID: 20389288. Pubmed Central PMCID: 2911250.
56.       Collins SA, Buhles A, Scallan MF, Harrison PT, O'Hanlon DM, O'Sullivan GC, et al. AAV2-mediated in vivo immune gene therapy of solid tumours. Genet Vaccines Ther. 2010;8:8. PubMed PMID: 21172020. Pubmed Central PMCID: 3016353. Epub 2010/12/22. eng.
57.       Casey G, Cashman JP, Morrissey D, Whelan MC, Larkin JO, Soden DM, et al. Sonoporation mediated immunogene therapy of solid tumors. Ultrasound Med Biol. 2010 Mar;36(3):430-40. PubMed PMID: 20133039. Epub 2010/02/06. eng.
58.       Baban CK, Cronin M, O'Hanlon D, O'Sullivan GC, Tangney M. Bacteria as vectors for gene therapy of cancer. Bioeng Bugs. 2010 Nov;1(6):385-94. PubMed PMID: 21468205. Pubmed Central PMCID: 3056088. Epub 2011/04/07. Eng.
59.       Ahmad S, Casey G, Sweeney P, Tangney M, O'Sullivan GC. Optimised electroporation mediated DNA vaccination for treatment of prostate cancer. Genet Vaccines Ther. 2010;8(1):1. PubMed PMID: 20181099. Pubmed Central PMCID: 2829554. Epub 2010/02/26. eng.
60.       Buhles A, Collins SA, van Pijkeren JP, Rajendran S, Miles M, O'Sullivan GC, et al. Anti-metastatic effects of viral and non-viral mediated Nk4 delivery to tumours. Genet Vaccines Ther. 2009;7:5. PubMed PMID: 19272140. Pubmed Central PMCID: 2669068. Epub 2009/03/11. eng.
61.       Ahmad S, Casey G, Sweeney P, Tangney M, O'Sullivan GC. Prostate stem cell antigen DNA vaccination breaks tolerance to self-antigen and inhibits prostate cancer growth. Mol Ther. 2009 Jun;17(6):1101-8. PubMed PMID: 19337234. Pubmed Central PMCID: 2835175.
62.       Larkin JO, Casey GD, Tangney M, Cashman J, Collins CG, Soden DM, et al. Effective tumor treatment using optimized ultrasound-mediated delivery of bleomycin. Ultrasound Med Biol. 2008 Mar;34(3):406-13. PubMed PMID: 17988788. Epub 2007/11/09. eng.
63.       Guinn B, Casey G, Collins S, O'Brien T, Alexander MY, Tangney M. Tripartite meeting in gene and cell therapy, 2008: Irish Society for Gene and Cell Therapy, British Society for Gene Therapy, and International Society for Cell and Gene Therapy of Cancer. Hum Gene Ther. 2008 Oct;19(10):967-78. PubMed PMID: 18652546. Epub 2008/07/26. eng.
64.       Collins SA, Guinn BA, Harrison PT, Scallan MF, O'Sullivan GC, Tangney M. Viral vectors in cancer immunotherapy: which vector for which strategy? Curr Gene Ther. 2008 Apr;8(2):66-78. PubMed PMID: 18393828. Epub 2008/04/09. eng.
65.       Cashman JP, Larkin JO, Casey G, Whelan MC, Collins C, Aarons S, et al. Immune gene therapy as a neoadjuvant to surgical excision to control metastatic cancers. Cancer Lett. 2008 April 8;262(1):94-102. PubMed PMID: 18179863. Epub 2008/01/09. Eng.
66.       Riedel CU, Monk IR, Casey PG, Morrissey D, O'Sullivan GC, Tangney M, et al. Improved luciferase tagging system for Listeria monocytogenes allows real-time monitoring in vivo and in vitro. Appl Environ Microbiol. 2007 May;73(9):3091-4. PubMed PMID: 17351089. Pubmed Central PMCID: 1892880. Epub 2007/03/14. eng.
67.       O'Sullivan GC, Tangney M, Casey G, Ambrose M, Houston A, Barry OP. Modulation of p21-activated kinase 1 alters the behavior of renal cell carcinoma. Int J Cancer. 2007 Nov 1;121(9):1930-40. PubMed PMID: 17621631. Epub 2007/07/11. eng.
68.       Larkin JO, Collins CG, Aarons S, Tangney M, Whelan M, O'Reily S, et al. Electrochemotherapy: aspects of preclinical development and early clinical experience. Ann Surg. 2007 Mar;245(3):469-79. PubMed PMID: 17435555. Pubmed Central PMCID: 1877027. Epub 2007/04/17. eng.
69.       Walsh M, Tangney M, O'Neill MJ, Larkin JO, Soden DM, McKenna SL, et al. Evaluation of cellular uptake and gene transfer efficiency of pegylated poly-L-lysine compacted DNA: implications for cancer gene therapy. Mol Pharm. 2006 Nov-Dec;3(6):644-53. PubMed PMID: 17140252. Epub 2006/12/05. eng.
70.       Tangney M, Casey G, Larkin JO, Collins CG, Soden D, Cashman J, et al. Non-viral in vivo immune gene therapy of cancer: combined strategies for treatment of systemic disease. Cancer Immunol Immunother. 2006 Nov;55(11):1443-50. PubMed PMID: 16612593. Epub 2006/04/14. eng.
71.       Soden DM, Larkin JO, Collins CG, Tangney M, Aarons S, Piggott J, et al. Successful application of targeted electrochemotherapy using novel flexible electrodes and low dose bleomycin to solid tumours. Cancer Lett. 2006 Feb 8;232(2):300-10. PubMed PMID: 15964138. Epub 2005/06/21. eng.
72.       Larkin J, Tangney M, Collins C, Casey G, O'Brien MG, Soden D, et al. Oral immune tolerance mediated by suppressor T cells may be responsible for the poorer prognosis of foregut cancers. Med Hypotheses. 2006;66(3):541-4. PubMed PMID: 16288967. Epub 2005/11/18. eng.
73.       Collins CG, Tangney M, Larkin JO, Casey G, Whelan MC, Cashman J, et al. Local gene therapy of solid tumors with GM-CSF and B7-1 eradicates both treated and distal tumors. Cancer Gene Ther. 2006 Dec;13(12):1061-71. PubMed PMID: 16874363. Epub 2006/07/29. eng.
74.       Larkin J, Soden D, Collins C, Tangney M, Preston JM, Russell LJ, et al. Combined electric field and ultrasound therapy as a novel anti-tumour treatment. Eur J Cancer. 2005 Jun;41(9):1339-48. PubMed PMID: 15913991. Epub 2005/05/26. eng.
75.       Casey PG, Casey GD, Gardiner GE, Tangney M, Stanton C, Ross RP, et al. Isolation and characterization of anti-Salmonella lactic acid bacteria from the porcine gastrointestinal tract. Lett Appl Microbiol. 2004;39(5):431-8. PubMed PMID: 15482434. Epub 2004/10/16. eng.
76.       Casey PG, Butler D, Gardiner GE, Tangney M, Simpson P, Lawlor PG, et al. Salmonella carriage in an Irish pig herd: correlation between serological and bacteriological detection methods. J Food Prot. 2004 Dec;67(12):2797-800. PubMed PMID: 15633689. Epub 2005/01/07. eng.
77.       Tangney M, Fitzgerald GF. Effectiveness of the lactococcal abortive infection systems AbiA, AbiE, AbiF and AbiG against P335 type phages. FEMS Microbiol Lett. 2002 Apr 23;210(1):67-72. PubMed PMID: 12023079. Epub 2002/05/23. eng.
78.       Tangney M, Fitzgerald GF. AbiA, a lactococcal abortive infection mechanism functioning in Streptococcus thermophilus. Appl Environ Microbiol. 2002 Dec;68(12):6388-91. PubMed PMID: 12450864. Pubmed Central PMCID: 134376. Epub 2002/11/27. eng.
79.       Rince A, Tangney M, Fitzgerald GF. Identification of a DNA region from lactococcal phage sk1 protecting phage 712 from the abortive infection mechanism AbiF. FEMS Microbiol Lett. 2000 Jan 1;182(1):185-91. PubMed PMID: 10612752. Epub 1999/12/29. eng.
80.       O'Connor L, Tangney M, Fitzgerald GF. Expression, regulation, and mode of action of the AbiG abortive infection system of lactococcus lactis subsp. cremoris UC653. Appl Environ Microbiol. 1999 Jan;65(1):330-5. PubMed PMID: 9872803. Pubmed Central PMCID: 91026. Epub 1999/01/05 21:58. Eng.